In vitro activity of gemifloxacin against recent clinical isolates of bacteria in Korea
- Authors
- Yong, Dongeun; Cheong, Hee Jin; Kim, Yang Soo; Park, Yeon Joon; Kim, Woo Joo; Woo, Jun Hee; Lee, Kyungwon; Kang, Moon Won; Choo, Youn-Sung
- Issue Date
- Dec-2002
- Publisher
- 대한의학회
- Keywords
- fluoroquinolone; gemifloxacin; Korea; Streptococcus pneumoniae; Haemophilus influenzae
- Citation
- Journal of Korean Medical Science, v.17, no.6, pp 737 - 742
- Pages
- 6
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Korean Medical Science
- Volume
- 17
- Number
- 6
- Start Page
- 737
- End Page
- 742
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/21631
- DOI
- 10.3346/jkms.2002.17.6.737
- ISSN
- 1011-8934
1598-6357
- Abstract
- Gemifloxacin is an enhanced-affinity fluoroquinolone with broad-spectrum antibacterial activity. In Korea, resistant bacteria are relatively more prevalent than in other industrialized countries. In this study, we studied the in vitro activities of gemifloxacin, moxifloxacin, levofloxacin, ciprofloxacin, and other commonly used gatifloxacin, antimicrobial agents against 1,689 bacterial strains isolated at four Korean university hospitals during 1999-2000. Minimum inhibitory concentrations (MICs) were determined using the agar dilution method of National Committee for Clinical Laboratory Standards. Gemifloxacin had the lowest MICs for the respiratory pathogens: 90% of Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were inhibited by 0.06, 0.03, and 0.03 mg/L, respectively. Gemifloxacin was more active than the other fluoroquinolones against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci, streptococci, and Enterococcus faecalis. The MIC90s of gemifloxacin for Klebsiella oxytoca, Proteus vulgaris, and non-typhoidal Salmonella spp. were 0.25, 1.0, and 0.12 mg/L, respectively, while those for other Gram-negative bacilli were 4-64 mg/L. In conclusion, gemifloxacin was the most active among the comparative agents against Gram-positive species, including respiratory pathogens isolated in Korea.
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Collections - 2. Clinical Science > Department of Infectious Diseases > 1. Journal Articles
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