Detailed Information

Cited 16 time in webofscience Cited 15 time in scopus
Metadata Downloads

alpha-Melanocyte stimulating hormone (MSH) decreases cyclosporine A induced apoptosis in cultured human proximal tubular cells

Authors
Jo, SKLee, SYHan, SYCha, DRCho, WYKim, HKWon, NH
Issue Date
Oct-2001
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
alpha-MSH; apoptosis; cyclosporine nephrotoxicity; Fas system
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.16, no.5, pp.603 - 609
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
16
Number
5
Start Page
603
End Page
609
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/22359
DOI
10.3346/jkms.2001.16.5.603
ISSN
1011-8934
Abstract
The pathogenesis of chronic cyclosporine A (CsA) nephrotoxicity has not been elucidated, but apoptosis is thought to play an important role in CsA induced tubular atrophy. Recently Fas-Fas ligand system mediated apoptosis has been frequently reported in many epithelial cells as well as in T lymphocytes. We investigated the ability of CsA to induce apoptosis in cultured human proximal tubular epithelial cells and also the effect of alpha -MSH on them. Fas, Fas ligand, and an intracellular adaptor protein, Fas-associating protein with death domain (FADD) expression, and poly-ADP ribose polymerase (PARP) cleavage were also studied. CsA induced apoptosis in cultured tubular epithelial cells demonstrated by increased number of TUNEL positive cells and it was accompanied by a significant increase in Fas mRNA and Fas ligand protein expressions. FADD and the cleavage product of PARP also increased, indicating the activation of caspase. In alpha -MSH co-treated cells, apoptosis markedly decreased with downregulation of Fas, Fas ligand and FADD expressions and also the cleavage product of PARP. In conclusion, these data suggest that tubular cell apoptosis mediated by Fas system may play a role in tubular atrophy in chronic CsA nephrotoxicity and pretreatment of alpha -MSH may have a some inhibitory effect on CsA induced tubular cell apoptosis.
Files in This Item
There are no files associated with this item.
Appears in
Collections
1. Basic Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Cho, Won Yong photo

Cho, Won Yong
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE