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Fra-1 expression in malignant and benign thyroid tumor.

Authors
Kim Y.H.Oh J.H.Kim N.H.Choi K.M.Kim S.J.Baik S.H.Choi D.S.Lee E.S.
Issue Date
Jun-2001
Citation
The Korean journal of internal medicine, v.16, no.2, pp 93 - 97
Pages
5
Indexed
SCOPUS
Journal Title
The Korean journal of internal medicine
Volume
16
Number
2
Start Page
93
End Page
97
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/22495
ISSN
1226-3303
2005-6648
Abstract
BACKGROUND: The differential diagnosis of thyroid nodules is very important in deciding the treatment modality and the fine needle aspiration is the best diagnostic method. But, there are some limitations in use because of inadequate test materials and difficulty in interpreting. According to the study of oncogene and tumor suppressor gene about the origin of thyroid tumor, expression of Fra-1, one of AP-1 complex, is increased in thyroid neoplasm, though not present in the normal tissue. So, there is a possibility that it will be used as a method for the differential diagnosis of thyroid nodules. We tried to know whether presence or absence of Fra-1 expression can be used as a diagnostic method in differential diagnosis of thyroid nodules using the immunohistochemical (IHC) staining method. METHODS: In 4 types of thyroid tumor that were confirmed by histologic diagnosis after operation (18 cases of adenomatous goiter, 16 cases of follicular adenoma, 30 cases of papillary cancer, 10 cases of follicular cancer), IHC staining method was performed to evaluate the expression of Fra-1. RESULTS: In papillary and follicular thyroid cancers, the expression of Fra-1 was stronger than in benign thyroid tumor, but there was no difference in Fra-1 expression between the two types of carcinoma. Weak expression of Fra-1 was observed in all cases of follicular adenoma, though it was weaker than in carcinoma, and it was also weakly expressed only in some cases (33%) of adenomatous goiter. CONCLUSION: The expression of Fra-1 was stronger in thyroid cancer than in benign thyroid tumor, but it was impossible to differentiate thyroid cancer from benign thyroid tumor by presence or absence of Fra-1 expression using IHC staining method.
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2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
2. Clinical Science > Department of Cardiology > 1. Journal Articles

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Baik, Sei Hyun
Guro Hospital (Department of Endocrinology and Metabolism, Guro Hospital)
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