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A case of BOOP developed during bucillamine treatment for rheumatoid.

Authors
Lee Y.H.Kim Y.R.Ji J.D.Shim J.J.Kang K.H.Lee J.H.Kim H.K.Song G.G.
Issue Date
2001
Keywords
bonchiolitis obliterans; rheumatoid arthritis
Citation
The Korean journal of internal medicine, v.16, no.1, pp 36 - 39
Pages
4
Indexed
SCOPUS
Journal Title
The Korean journal of internal medicine
Volume
16
Number
1
Start Page
36
End Page
39
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/22829
DOI
10.3904/kjim.2001.16.1.36
ISSN
1226-3303
2005-6648
Abstract
We describe a patient with rheumatoid arthritis(RA) who developed bronchiolitis obliterans organizing pneumonia(BOOP) during the treatment of bucillamine. A 51 year-old man was admitted to the hospital for an abnormal shadow on his chest radiograph. He had been diagnosed as having RA 3 years previously and had been receiving 200 mg of bucillamine for 21 months. Two months prior to admission, he presented with a cough and his chest X-ray showed opacities in both lower lungs. He was treated with antibiotics for 2 months after the development of cough and lesions on the chest X-ray, but the symptoms and lung lesions became more aggravated. On admission, an HRCT revealed airspace consolidations in the subpleural space of both basal lungs and a CT-guided fine needle aspiration biopsy showed Masson's body filling air space, interstitial infiltration of acute and chronic inflammatory cells and type II cell hyperplasia, consistent with BOOP. Bucillamine was stopped and 50 mg of prednisolone was administered. His symptoms and infiltrations on the chest X-ray resolved. We suggest that bucillamine should be considered as a drug possibly associated with BOOP.
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2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Pulmonary, Allergy, and Critical Care Medicine > 1. Journal Articles
2. Clinical Science > Department of Rheumatology > 1. Journal Articles

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Shim, Jae Jeong
Guro Hospital (Department of Pulmonary, Allergy, and Critical Care Medicine, Guro Hospital)
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