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Cited 36 time in webofscience Cited 47 time in scopus
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Risperidone and associated amenorrhea: A report of 5 cases

Authors
Kim, YKKim, LLee, MS
Issue Date
May-1999
Publisher
PHYSICIANS POSTGRADUATE PRESS
Keywords
Risperidone; Amenorrhea
Citation
JOURNAL OF CLINICAL PSYCHIATRY, v.60, no.5, pp 315 - 317
Pages
3
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF CLINICAL PSYCHIATRY
Volume
60
Number
5
Start Page
315
End Page
317
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/24002
DOI
10.4088/JCP.v60n0509
ISSN
0160-6689
1555-2101
Abstract
Background: We report a 5-case series in which risperidone use in usual or lower-than-usual doses was unexpectedly associated with amenorrhea. Case Reports: On regimens of risperidone (1-8 mg/day), 5 psychiatric patients with various diagnoses developed amenorrhea with elevated serum prolactin levels (mean = 121.7 ng/mL; range, 61.2-229.8 ng/mL). In 4 of 5 cases, menstruation resumed only when risperidone was withdrawn, and in 1 case, menstruation restarted when the dose was tapered. Follow-up serum prolactin levels dropped to a mean of 17.2 ng/mL (range, 6.4-37.6 ng/mL). Conclusion: These findings indicate that the occurrence of amenorrhea during risperidone treatment may be related to elevated serum prolactin levels. This phenomenon may be due either to the dopamine D-2 blocking effect of risperidone or to the large individual variability in the rate at which risperidone is metabolized.
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Kim, Leen
Anam Hospital (Department of Psychiatry, Anam Hospital)
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