Risperidone and associated amenorrhea: A report of 5 cases
- Authors
- Kim, YK; Kim, L; Lee, MS
- Issue Date
- May-1999
- Publisher
- PHYSICIANS POSTGRADUATE PRESS
- Keywords
- Risperidone; Amenorrhea
- Citation
- JOURNAL OF CLINICAL PSYCHIATRY, v.60, no.5, pp 315 - 317
- Pages
- 3
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL PSYCHIATRY
- Volume
- 60
- Number
- 5
- Start Page
- 315
- End Page
- 317
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/24002
- DOI
- 10.4088/JCP.v60n0509
- ISSN
- 0160-6689
1555-2101
- Abstract
- Background: We report a 5-case series in which risperidone use in usual or lower-than-usual doses was unexpectedly associated with amenorrhea. Case Reports: On regimens of risperidone (1-8 mg/day), 5 psychiatric patients with various diagnoses developed amenorrhea with elevated serum prolactin levels (mean = 121.7 ng/mL; range, 61.2-229.8 ng/mL). In 4 of 5 cases, menstruation resumed only when risperidone was withdrawn, and in 1 case, menstruation restarted when the dose was tapered. Follow-up serum prolactin levels dropped to a mean of 17.2 ng/mL (range, 6.4-37.6 ng/mL). Conclusion: These findings indicate that the occurrence of amenorrhea during risperidone treatment may be related to elevated serum prolactin levels. This phenomenon may be due either to the dopamine D-2 blocking effect of risperidone or to the large individual variability in the rate at which risperidone is metabolized.
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- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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