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Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea
- Authors
- Kim, YK; Kim, SH; Choi, SH; Ko, YH; Kim, L; Lee, MS; Suh, KY; Kwak, DI; Song, KJ; Lee, YJ; Yanagihara, R; Song, JW
- Issue Date
- Apr-1999
- Publisher
- STOCKTON PRESS
- Keywords
- Borna disease virus; RT-PCR; PBMC; psychiatric disorders
- Citation
- JOURNAL OF NEUROVIROLOGY, v.5, no.2, pp 196 - 199
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NEUROVIROLOGY
- Volume
- 5
- Number
- 2
- Start Page
- 196
- End Page
- 199
- ISSN
- 1355-0284
1538-2443
- Abstract
- RNA, extracted from peripheral blood mononuclear cells (PBMSC) obtained ham 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein-encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase chain reaction (RT - PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.
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Related Researcher
- Suh, Kwang Yoon
- Anam Hospital (Department of Psychiatry, Anam Hospital)