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Cited 16 time in webofscience Cited 15 time in scopus
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EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas

Authors
Lee, Jae MinChoi, Hyuk SoonChun, Hoon JaiKim, Eun SunKeum, BoraSeo, Yeon SeokJeen, Yoon TaeLee, Hong SikUm, Soon HoKim, Chang DuckKim, Hong Bae
Issue Date
Feb-2019
Publisher
SPRINGER
Keywords
Irreversible electroporation; Pancreas; Endoscopy; EUS; Animal
Citation
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, v.33, no.2, pp.658 - 662
Indexed
SCIE
SCOPUS
Journal Title
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
Volume
33
Number
2
Start Page
658
End Page
662
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2415
DOI
10.1007/s00464-018-6425-4
ISSN
0930-2794
Abstract
BackgroundEndoscopic irreversible electroporation (IRE) can be performed using a flexible, thin, needle-shaped electrode for an endoscopic ultrasound (EUS)-guided procedure. This study aimed to evaluate the feasibility and efficacy of performing EUS-guided IRE with endoscopic needle-electrode in porcine pancreas.MethodsExperimental endoscopic IRE on the pancreas were performed by EUS-guided approach in three pigs and compared with surgical approach in three pigs. The animals were killed after 24h and their pancreases collected.ResultsIRE ablation using endoscopic needle-electrode was successful technically in EUS-guided approaches for the pancreas. Immediately following IRE, the ablated pancreatic tissue showed no gross change except focal hemorrhage. H&E staining presented a well-demarcated ablation site measuring 1.0-1.5cm in diameter in the pancreas. TUNEL immunohistochemistry showed diffuse cell death along the puncture site 24h after IRE. No complication was observed in pigs after endoscopic IRE ablation.ConclusionEUS-guided IRE ablation was feasible and effective for pancreas using the newly developed device.
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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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