Decreased interleukin-2 production in Korean schizophrenic patients
- Authors
- Kim, YK; Lee, MS; Suh, KY
- Issue Date
- 1-May-1998
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- schizophrenia; interleukin; autoimmune hypothesis; ethnicity
- Citation
- BIOLOGICAL PSYCHIATRY, v.43, no.9, pp 701 - 704
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOLOGICAL PSYCHIATRY
- Volume
- 43
- Number
- 9
- Start Page
- 701
- End Page
- 704
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/24614
- DOI
- 10.1016/S0006-3223(97)00357-0
- ISSN
- 0006-3223
1873-2402
- Abstract
- Background: It has been postulated that autoimmune process may play a role in the pathogenesis of symptoms in some schizophrenic patients. Findings of altered interleukin (IL) regulation have been regarded as additional proof that schizophrenia has an autoimmunological background. Methods: Sixteen patients who fulfilled DSM-IV criteria for schizophrenia and who were drug free for at least six months and the same number of age-and sex-matched controls were recruited The severity of symptoms in schizophrenia was assessed by BPRS. Phytohemagglutinin (PHA)-stimulated production and serum level of IL-1 beta, IL-2, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Results: There was a significant decrease of IL-2 production (p < .01) in schizophrenic patients and a significant increase of IL-2 serum level (p < .01). No significant difference of IL-1 beta and IL-6 was found. Some patients and controls had measurable serum level of IL-I beta and IL-6. No significant correlation between production and serum level of IL-I beta, -2, -6 and age, duration of illness, and BPRS score in schizophrenics was found Conclusions: This is the first study to describe a decrease of IL-2 production and increase of IL-2 serum level in non-Caucasian schizophrenic patients. These findings are further evidence that autoimmune process is present, regardless of ethnic origin, in some schizophrenic patients. (C) 1998 Society of Biological Psychiatry.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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