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Cited 11 time in webofscience Cited 12 time in scopus
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Electrical stimulation accelerates neurite regeneration in axotomized dorsal root ganglion neurons by increasing MMP-2 expression

Authors
Han, SungminKim, Dong HweeSung, JoohwanYang, HwasunPark, Jong WoongYoun, Inchan
Issue Date
8-Jan-2019
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Electrical stimulation; Matrix metalloproteinase; Neurite regeneration; Dorsal root ganglion
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.508, no.2, pp 348 - 353
Pages
6
Indexed
SCI
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
508
Number
2
Start Page
348
End Page
353
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2488
DOI
10.1016/j.bbrc.2018.11.159
ISSN
0006-291X
1090-2104
Abstract
Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration. Our data suggest that the positive effect of ES on neurite regeneration could likely be mediated by an increase in MMP-2 expression, thereby promoting the regeneration of injured neurites. (C) 2018 Elsevier Inc. All rights reserved.
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Park, Jong Woong
Anam Hospital (Department of Orthopedic Surgery, Anam Hospital)
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