Detailed Information

Cited 15 time in webofscience Cited 20 time in scopus
Metadata Downloads

Double-blind placebo-controlled study of cisapride in patients with nonspecific esophageal motility disorder accompanied by delayed esophageal transit

Authors
Song, CWUm, SHKim, CDRyu, HSHyun, JHChoe, JG
Issue Date
Jun-1997
Publisher
SCANDINAVIAN UNIVERSITY PRESS
Keywords
cisapride; esophageal motility disorder; esophageal peristalsis; esophageal transit; nonspecific esophageal motility disorder
Citation
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.32, no.6, pp.541 - 546
Indexed
SCIE
SCOPUS
Journal Title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume
32
Number
6
Start Page
541
End Page
546
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/25295
DOI
10.3109/00365529709025096
ISSN
0036-5521
Abstract
Background: Nonspecific esophageal motility disorder (NEMD) represents a difficult therapeutic of cisapride on the esophageal symptoms and esophageal motor function in a group of patients with NEMD showing delayed esophageal transit. Methods: Seventy eligible patients were entered into a 4-week, double-blind randomized comparison of 10 mg of cisapride or placebo, four times daily. Symptom assessment, esophageal manometry after wet swallows, and esophageal scintigraphy after intake of a liquid and solid bolus were performed in each patient before and after treatment. Results: After 4 weeks of treatment cisapride significantly increased the prevalence of esophageal peristaltic contractions (percentage of total contractions, P < 0.05 versus base line and placebo) and significantly improved esophageal emptying of the solid bolus (P < 0.05 versus placebo) but not of the liquid bolus. Placebo did nor have any significant effects versus base line on these variables. Both placebo and cisapride improved the distal esophageal amplitude versus base line (no significant intergroup differences). Symptom scores were significantly reduced after 4 weeks of treatment versus base line in both groups (no significant intergroup differences except for heartburn and regurgitation, P < 0.05). On global evaluation of treatment, significantly more patients in the cisapride group were rated as markedly or moderately improved, when compared with placebo. Conclusions: The results of the present study showed that cisapride is effective and well tolerated in patients with NEMD accompanied by delayed esophageal transit. Symptomatic improvement may possibly be related to its beneficial action on the esophageal body by increasing the number of peristaltic contractions and esophageal emptying of solids.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Nuclear Medicine > 1. Journal Articles
2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Hyun, Jin Hai photo

Hyun, Jin Hai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE