Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Morphologic Alterations in Amygdala Subregions of Adult Patients with Bipolar Disorder

Authors
이현재한규만김아람강우영강유빈강준원은수태우석함병주
Issue Date
2019
Publisher
대한생물정신의학회
Keywords
Bipolar disorder; Magnetic resonance imaging; Amygdala; Basolateral nuclear complex; Image processing; computer-assisted; Lithium.; 양극성 장애; 자기공명영상; 편도체; 소부위; 피질하 용적; 리튬
Citation
생물정신의학, v.26, no.1, pp 22 - 31
Pages
10
Indexed
KCI
Journal Title
생물정신의학
Volume
26
Number
1
Start Page
22
End Page
31
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2631
DOI
10.22857/kjbp.2019.26.1.004
ISSN
1225-8709
Abstract
Objectives : Previous studies have revealed inconsistent results on amygdala volume in adult bipolar disorder (BD) patients compared to healthy controls (HC). Since the amygdala encompasses multiple subregions, the subtle volume changes in each amygdala nucleus might have not been fully reflected in the measure of the total amygdala volume, causing discrepant results. Thus, we aimed to investigate volume changes in each amygdala subregion and their association with subtypes of BD, lithium use and clinical status of BD. Methods : Fifty-five BD patients and 55 HC underwent T1-weighted structural magnetic resonance imaging. We analyzed volumes of the whole amygdala and each amygdala subregion, including the anterior amygdaloid area, cortico-amygdaloid transition area, basal, lateral, accessory basal, central, cortical, medial and paralaminar nuclei using the atlas in the FreeSurfer. The volume difference was analyzed using a one-way analysis of covariance with individual volumes as dependent variables, and age, sex, and total intracranial volume as covariates. Results : The volumes of whole right amygdala and subregions including basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area in the right amygdala of BD patients were significantly smaller for the HC group. No significant volume difference between bipolar I disorder and bipolar II disorder was found after the Bonferroni correction. The trend of larger volume in medial nucleus with lithium treatment was not significant after the Bonferroni correction. No significant correlation between illness duration and amygdala volume, and insignificant negative correlation were found between right central nucleus volume and depression severity. Conclusions : Significant volume decrements of the whole amygdala, basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area were found in the right hemisphere in adult BD patients, compared to HC group. We postulate that such volume changes are associated with altered functional activity and connectivity of amygdala nuclei in BD.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Psychiatry > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Han, Kyu-Man photo

Han, Kyu-Man
Anam Hospital (Department of Psychiatry, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE