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Cited 28 time in webofscience Cited 28 time in scopus
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Electroconvulsive Shock Reduces Inositol 1,4,5-Trisphosphate 3-Kinase mRNA Expression in Rat Dentate Gyrus

Authors
Kim, HyunKo, Jae PilKang, Ung GuPark, Joo-BaeKim, Hyung-LaeLee, Young HanKim, Yong Sik
Issue Date
Nov-1994
Publisher
Blackwell Publishing Inc.
Keywords
C-FOS; DENTATE GYRUS; ELECTROCONVULSIVE SHOCK; INOSITOL 1,4,5-TRIPHOSPHATE 3-KINASE; IN SITU HYBRIDIZATION HISTOCHEMISTRY
Citation
Journal of Neurochemistry, v.63, no.5, pp 1991 - 1994
Pages
4
Indexed
SCOPUS
Journal Title
Journal of Neurochemistry
Volume
63
Number
5
Start Page
1991
End Page
1994
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/26466
DOI
10.1046/j.1471-4159.1994.63051991.x
ISSN
0022-3042
1471-4159
Abstract
We investigated the expression of inositol 1,4,5-trisphosphate (InsP(3)) 3-kinase mRNA after a single electroconvulsive shock (ECS) with in situ hybridization histochemistry in rat brain. At 6 h after ECS, the expression was markedly decreased in the dentate gyrus, and the decrease was maintained until 9 h with a slight recovery. The InsP(3) 3-kinase mRNA content returned to basal levels after 12 h. We could not detect any apparent changes in the expression of InsP(3) 3-kinase mRNA in the CA1-CA3 areas of hippocampus, the striatum, and the cerebral cortex at any time point examined. In the temporal pattern, the reduction of the expression in the dentate gyrus was preceded by the induction of c- fos after ECS. These observations suggest that the InsP(3) 3-kinase might be one of the genes whose expression can be altered by ECS.
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