Early systemic failure after preoperative chemoradiotherapy for the treatment of patients with rectal cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi T. | - |
dc.contributor.author | Baek S.-J. | - |
dc.contributor.author | Kwak J.M. | - |
dc.contributor.author | Kim J. | - |
dc.contributor.author | Kim S.-H. | - |
dc.date.available | 2020-11-02T06:49:01Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 2287-9714 | - |
dc.identifier.issn | 2287-9722 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2716 | - |
dc.description.abstract | Purpose: Distant metastasis can occur early after neoadjuvant chemoradiotherapy (CRT) in patients with rectal cancer. This study was conducted to evaluate the clinical characteristics of patients who developed early systemic failure. Methods: The patients who underwent neoadjuvant CRT for a rectal adenocarcinoma between June 2007 and July 2015 were included in this study. Patients who developed distant metastasis within 6 months after CRT were identified. We compared short- and long-term clinicopathologic outcomes of patients in the early failure (EF) group with those of patients in the control group. Results: Of 107 patients who underwent neoadjuvant CRT for rectal cancer, 7 developed early systemic failure. The lung was the most common metastatic site. In the EF group, preoperative carcinoembryonic antigen was higher (5 mg/mL vs. 2 mg/mL, P = 0.010), and capecitabine as a sensitizer of CRT was used more frequently (28.6% vs. 3%, P = 0.002). Of the 7 patients in the EF group, only 4 underwent a primary tumor resection (57.1%), in contrast to the 100% resection rate in the control group (P < 0.001). In terms of pathologic outcomes, ypN and TNM stages were more advanced in the EF group (P < 0.001 and P = 0.047, respectively), and numbers of positive and retrieved lymph nodes were much higher (P < 0.001 and P = 0.027, respectively). Conclusion: Although early distant metastasis after CRT for rectal cancer is very rare, patients who developed early metastasis showed a poor nodal response with a low primary tumor resection rate and poor oncologic outcomes. © 2019 The Korean Society of Coloproctology | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society of Coloproctology | - |
dc.title | Early systemic failure after preoperative chemoradiotherapy for the treatment of patients with rectal cancer | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3393/ac.2018.10.01 | - |
dc.identifier.scopusid | 2-s2.0-85070228406 | - |
dc.identifier.wosid | 000466965400006 | - |
dc.identifier.bibliographicCitation | Annals of Coloproctology, v.35, no.2, pp 94 - 99 | - |
dc.citation.title | Annals of Coloproctology | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 94 | - |
dc.citation.endPage | 99 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002463675 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | bevacizumab | - |
dc.subject.keywordPlus | capecitabine | - |
dc.subject.keywordPlus | carcinoembryonic antigen | - |
dc.subject.keywordPlus | fluorouracil | - |
dc.subject.keywordPlus | oxaliplatin | - |
dc.subject.keywordPlus | tegafur | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | anal canal | - |
dc.subject.keywordPlus | anastomosis leakage | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | bone metastasis | - |
dc.subject.keywordPlus | cancer adjuvant therapy | - |
dc.subject.keywordPlus | cancer staging | - |
dc.subject.keywordPlus | cancer surgery | - |
dc.subject.keywordPlus | chemoradiotherapy | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | distant metastasis | - |
dc.subject.keywordPlus | emergency surgery | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | hartmann procedure | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | liver metastasis | - |
dc.subject.keywordPlus | lung metastasis | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | middle aged | - |
dc.subject.keywordPlus | operation duration | - |
dc.subject.keywordPlus | pelvic girdle | - |
dc.subject.keywordPlus | preoperative care | - |
dc.subject.keywordPlus | preoperative evaluation | - |
dc.subject.keywordPlus | primary tumor | - |
dc.subject.keywordPlus | rectum carcinoma | - |
dc.subject.keywordPlus | treatment failure | - |
dc.subject.keywordPlus | tumor volume | - |
dc.subject.keywordAuthor | Chemoradiotherapy | - |
dc.subject.keywordAuthor | Distant metastasis | - |
dc.subject.keywordAuthor | Neoadjuvant therapy | - |
dc.subject.keywordAuthor | Rectal neoplasms | - |
dc.subject.keywordAuthor | Systemic failure | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.