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Cited 58 time in webofscience Cited 62 time in scopus
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Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells

Authors
Jeong, SoyeonYun, Hye KyeongJeong, Yoon A.Jo, Min JeeKang, Sang HeeKim, Jung LimKim, Dae YeongPark, Seong HyeKim, Bo RamNa, Yoo JinLee, Sun IlKim, Han DoKim, Dae HyunOh, Sang CheulLee, Dae-Hee
Issue Date
Apr-2019
Publisher
ELSEVIER IRELAND LTD
Keywords
Marijuana extract; Bcl-2 protein family; ROS; Apoptotic cell death; Colon cancer
Citation
CANCER LETTERS, v.447, pp.12 - 23
Indexed
SCIE
SCOPUS
Journal Title
CANCER LETTERS
Volume
447
Start Page
12
End Page
23
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2762
DOI
10.1016/j.canlet.2019.01.011
ISSN
0304-3835
Abstract
Cannabidiol (CBD), one of the compounds present in the marijuana plant, has anti-tumor properties, but its mechanism is not well known. This study aimed to evaluate the apoptotic action of CBD in colorectal cancer (CRC) cells, and focused on its effects on the novel pro-apoptotic Noxa-reactive oxygen species (ROS) signaling pathway. CBD experiments were performed using the CRC cell lines HCT116 and DLD-1. CBD induced apoptosis by regulating many pro- and anti-apoptotic proteins, of which Noxa showed significantly higher expression. To understand the relationship between Noxa and CBD-induced apoptosis, Noxa levels were downregulated using siRNA, and the expression of apoptosis markers decreased. After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents. As a result, CBD induced apoptosis in a Noxa-and-ROS-dependent manner. Taken together, the results obtained in this study re-demonstrated the effects of CBD treatment in vivo, thus confirming its role as a novel, reliable anticancer drug.
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3. Graduate School > Graduate School > 1. Journal Articles
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles

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Lee, Sun Il
Guro Hospital (Department of Colon and Rectal Surgery, Guro Hospital)
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