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Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells
- Authors
- Kim, Jae-Young; Youn, Hwa Young; Choi, June; Baek, Seung Kuk; Kwon, Soon Young; Eun, Bok Kee; Park, Jae-Yong; Oh, Kyoung Ho
- Issue Date
- 2019
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Anoctamin; thyroid cancer; invasion; migration
- Citation
- ANIMAL CELLS AND SYSTEMS, v.23, no.4, pp 294 - 301
- Pages
- 8
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANIMAL CELLS AND SYSTEMS
- Volume
- 23
- Number
- 4
- Start Page
- 294
- End Page
- 301
- ISSN
- 1976-8354
2151-2485
- Abstract
- Anaplastic thyroid carcinoma (ATC) is a rare malignancy with very poor prognosis. The exact cause underlying its strong aggressive nature is not clear. Here, we discovered the elevated expression of anoctamin-1 (ANO1; Ca2+-activated Cl- channels) in advanced-stage ATC tissue. Using different ATC cell lines, the degree of expression of ANO1 was found to be related to the degree of ATC cell invasion by quantitative reverse transcription polymerase chain reaction and western blotting. Suppression of ANO1 activity either by selective inhibitor (T16Ainh-A01) or by siRNA significantly attenuated the migration and invasion of ATC cells. In conclusion, ANO1 appears to increase the ability of ATC cells to invade and migrate. Our results also suggest that the expression of ANO1 in patients with ATC may be helpful in predicting the prognosis of ATC.
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Related Researcher
- Oh, Kyoung Ho
- Ansan Hospital (Department of Otorhinolaryngology-Head and Neck Surgery, Ansan Hospital)