"Choosing Wisely": Apolipoprotein E Genetic Testing for the Diagnosis of Alzheimer's Disease in Dementia Clinics
- Authors
- Yang, Hyun Ju; Kang, Na Ri; Jung, Young Eun; Kim, Moon Doo; Jeong, Hyun Ghang; Lee, Tae Jin; Han, Ji Won; Kim, Ki Woong; Park, Joon Hyuk
- Issue Date
- Apr-2020
- Publisher
- IOS Press
- Keywords
- Alzheimer's disease; apolipoprotein genetic testing; odds ratio; sensitivity; specificity
- Citation
- Journal of Alzheimer's Disease, v.74, no.4, pp 1253 - 1260
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Alzheimer's Disease
- Volume
- 74
- Number
- 4
- Start Page
- 1253
- End Page
- 1260
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/28369
- DOI
- 10.3233/JAD-190983
- ISSN
- 1387-2877
1875-8908
- Abstract
- Background:
Apolipoprotein E (APOE) ɛ4 allele carriers have an increased risk of late-onset Alzheimer’s disease (AD). However, in the “Choosing Wisely” campaign for avoiding unnecessary medical tests, treatments, and procedures, APOE genetic testing is not recommended as a predictive test for AD.
Objective:
The aim of this study was to investigate the potential value of APOE genetic testing in a specific clinical context.
Methods:
Subjects with poor performance in the Korean version of the Mini-Mental Status Examination for dementia screening (MMSE-DS) with a Z-score of less than –1.5 were recruited from the public health centers. All participants underwent APOE genetic testing. Family history of dementia (FHx) was confirmed if one or more first-degree relatives had dementia.
Results:
Among 349 subjects, 162 (46.4%) were diagnosed with AD. APOE ɛ4 allele carriers had a much higher risk of AD in the group with FHx than in the group without FHx (OR = 15.81, 95% CI = 2.74–91.21 versus OR = 1.82, 95% CI = 1.00–3.27, z = 2.293, p = 0.011). The sensitivity, specificity, positive predictive value, and negative predictive value for the APOE ɛ4 allele were 47.7%, 90.9%, 91.3%, and 46.5% in the group with FHx.
Conclusion:
It would be a wise choice to perform the APOE genetic testing for the diagnosis of AD in subjects with poor performance in a screening test and a family history of dementia.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.