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Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitorsopen access
- Authors
- Park, Bernie Byunghoon; Choi, Jae Wan; Park, Dawon; Choi, Doyoung; Paek, Jiwon; Kim, Hyun Jung; Son, Se-Young; Ul Mushtaq, Ameeq; Shin, Hyeji; Kim, Sang Hoon; Zhou, Yuanyuan; Lim, Taehyeong; Park, Ji Young; Baek, Ji-Young; Kim, Kyul; Kwon, Hongmok; Son, Sang-Hyun; Chung, Ka Young; Jeong, Hyun-Ja; Kim, Hyung-Min; Jung, Yong Woo; Lee, Kiho; Lee, Ki Yong; Byun, Youngjoo; Jeon, Young Ho
- Issue Date
- Jun-2019
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.9
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 9
- ISSN
- 2045-2322
- Abstract
- Thymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting in eosinophilic inflammation and numerous allergic diseases. Baicalein (1), a major component of Scutellaria baicalensis, was found to be the first small molecule to block TSLP signaling pathways. It inhibited effectively eosinophil infiltration in house dust mite-induced and ovalbumin-challenged mouse models. Structure-activity relationship studies identified compound 11a, a biphenyl flavanone analog, as a novel human TSLP inhibitor for the discovery and development of new anti-allergic drugs.
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- KU, Med Lib
- Others (Others(Medicine))