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일주기리듬의 조절이상이 양극성장애의핵심 발병 기전일까?Is the Circadian Rhythm Dysregulation a Core Pathogenetic Mechanism of Bipolar Disorder?

Other Titles
Is the Circadian Rhythm Dysregulation a Core Pathogenetic Mechanism of Bipolar Disorder?
Authors
이헌정
Issue Date
Nov-2018
Publisher
대한신경정신의학회
Keywords
Bipolar disorder; Circadian rhythm; Pathogenetic mechanism.; 양극성장애·일주기리듬·발병기전
Citation
신경정신의학, v.57, no.4, pp.276 - 286
Indexed
KCI
OTHER
Journal Title
신경정신의학
Volume
57
Number
4
Start Page
276
End Page
286
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/29185
DOI
10.4306/jknpa.2018.57.4.276
ISSN
1015-4817
Abstract
Circadian rhythm is a periodic and continuous change in physiological, behavioral, and mental characteristics that occurs in most organisms on the Earth, because the Earth rotates in a 24- hour cycle. The circadian system regulates daily rhythms of physiology and behavior, such as the sleep/wake cycle, body temperature, hormonal secretion, and mood. The influence of circadian rhythm is very powerful, but limited research has addressed its effects. However, many recent studies have shown that circadian dysregulation may play an important role in the pathogenesis of bipolar disorder. This review study examined current and noteworthy studies, including the authors’ own works, and proposes a possible clinical application of bipolar disorder based on evidence that circadian rhythm dysregulation in bipolar disorder may be a key pathogenetic mechanism.
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Anam Hospital (Department of Psychiatry, Anam Hospital)
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