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Cited 12 time in webofscience Cited 10 time in scopus
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Changeable Conditional Survival Rates and Associated Prognosticators in Patients with Metastatic Renal Cell Carcinoma Receiving First Line Targeted Therapy

Authors
Kang, MinyongPark, Jae YoungJeong, Chang WookHwang, Eu ChangSong, CherynHong, Sung-HooKwak, CheolChung, JinsooSung, Hyun HwanJeon, Hwang GyunJeong, Byong ChangPark, Se HoonJeon, Seong SooLee, Hyun MooChoi, Han YongSeo, Seong Il
Issue Date
Nov-2018
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
kidney; carcinoma; renal cell; neoplasm metastasis; mortality; protein-tyrosine kinases
Citation
Journal of Urology, v.200, no.5, pp 989 - 995
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
Journal of Urology
Volume
200
Number
5
Start Page
989
End Page
995
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2962
DOI
10.1016/j.juro.2018.06.030
ISSN
0022-5347
1527-3792
Abstract
Purpose: In this study we evaluated conditional survival probabilities in patients with metastatic renal cell carcinoma who underwent first line tyrosine kinase inhibitor therapy. We also identified predictors of conditional survival with time. Materials and Methods: We retrospectively reviewed clinical data on 1,659 individuals with metastatic renal cell carcinoma in the Korean Renal Cancer Study Group database, of whom the records of 1,131 were finally analyzed. The primary end point was conditional overall survival. Kaplan-Meier survival analysis was used to calculate conditional overall survival probabilities using the formula, conditional survival (alpha vertical bar beta = S(alpha+ beta)/S(beta), indicating the likelihood of additional alpha years survivorship in person who has already survived for beta years after initial therapy. S(chi) represents the actual survival rate. Multivariate Cox regression model was used to identify predictors of conditional survival with time. Results: Six, 12, 18, 24 and 36-month conditional overall survival gradually increased in patients at all additional survival times after initial treatment compared to patient baseline survival estimations. While the actual overall survival rate decreased with time, the 36-month conditional overall survival rate was calculated as 7.3% higher in patients who had already survived 36 months compared to baseline estimations at the time of initial tyrosine kinase inhibitor treatment. Furthermore, predictors of conditional overall survival changed with time. Only previous metastasectomy remained a key prognosticator of conditional overall survival until 36 months of survival following initial tyrosine kinase inhibitor treatment. Conclusions: Conditional survival improved with time after initial tyrosine kinase inhibitor treatment in patients with metastatic renal cell carcinoma. Our study offers valuable information for practical survival estimations and relevant prognosticators in patients with metastatic renal cell carcinoma who receive first line tyrosine kinase inhibitor.
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Park, Jae Young
Ansan Hospital (Department of Urology, Ansan Hospital)
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