Detailed Information

Cited 5 time in webofscience Cited 10 time in scopus
Metadata Downloads

Dosimetric and Clinical Influence of 3D Versus 2D Planning in Postoperative Radiation Therapy for Gastric Canceropen access

Authors
Lee, Jung AeAhn, Yong ChanLim, Do HoonPark, Hee ChulAsranbaeva, Margarita S.
Issue Date
Oct-2015
Publisher
KOREAN CANCER ASSOCIATION
Keywords
Radiotherapy; Stomach neoplasms; Computer-assisted radiotherapy planning
Citation
CANCER RESEARCH AND TREATMENT, v.47, no.4, pp 727 - 737
Pages
11
Indexed
SCIE
SCOPUS
KCI
Journal Title
CANCER RESEARCH AND TREATMENT
Volume
47
Number
4
Start Page
727
End Page
737
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/29876
DOI
10.4143/crt.2014.018
ISSN
1598-2998
2005-9256
Abstract
Purpose The purpose of this study is to investigate the dosi metric and clinical influence of computed tomography-based (3-dimensional [3D]) simulation versus conventional 2-dimensional (2D)-based simulation in postoperative chemoradiotherapy (CRT) for patients with advanced gastric cancer in terms of parallel opposed a nteroposterior-posteroa nterior field arrangement. Materials and Methods A retrospective stage-matched cohort study was conducted in 158 patients treated with adjuvant CRT following curative surgery and 02 dissection from 2006 to 2008 at Samsung Medical Center: 98 patients in the 3D group; and 60 patients in the 2D group. For comparison of the dosimetric parameters between 3D plan and 20 plan, second sets of radiation treatment plans were generated according to the same target delineation method used in the 2D group for each patient in the 3D group (V2D). Acute toxicity, recurrence, and survival were analyzed. The median follow-up period was 28 months (range, 5 to 51 months). Results The 3D group showed better dose-volume histogram (DVH) profiles than the V2D group for all dosimetric parameters, including the kidneys, liver, spinal cord, duodenum, pancreas, and bowel. However, no difference in acute gastrointestinal toxicity and survival outcomes was observed between the 3D group and the 2D group. Conclusion The 3D plan enabled precise delineation of the target volume and organs at risk by visualization of geometric changes in the internal organs after surgery. The DVH of normal tissues in the 3D plan was superior to that of the V2D plan, but similar clinical features were observed between the 3D group and the 20 group.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Radiation Oncology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE