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Cited 17 time in webofscience Cited 20 time in scopus
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Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells

Authors
Kang, SangheeKim, Bo RamKang, Myoung-HeeKim, Dae-YoungLee, Dae-HeeOh, Sang CheulMin, Byung WookUm, Jun Won
Issue Date
11-Oct-2018
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.13, no.10
Indexed
SCIE
SCOPUS
Journal Title
PLOS ONE
Volume
13
Number
10
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3030
DOI
10.1371/journal.pone.0205449
ISSN
1932-6203
Abstract
Metformin, a first-line drug used to treat type 2 diabetes, has also been shown to have anti-cancer effects against a variety of malignancies, including colorectal cancer. Although inhibition of the mTOR pathway is known to be the most important mechanism for the antitumor effects of metformin, other mechanisms remain unclear. The purpose of this study was to identify the antitumor mechanism of metformin in colorectal cancer using high-throughput data, and then test the mechanism experimentally. We identified the gene signature of metformin-treated colon cancer cells. This signature was processed for prediction using colon adenocarcinoma patient data from the Cancer Genome Atlas to classify the patients showing a gene expression pattern similar to that in metformin-treated cells. This patient group showed better overall and disease-free survival. Furthermore, pathway analysis revealed that the metformin-predicted group was characterized by decreased interleukin (IL)-6 pathway signaling, epithelial-mesenchymal transition, and colon cancer metastatic signaling. We induced epithelial-mesenchymal transition in colon cancer cell lines via IL-6 treatment, which increased cell motility and promoted invasion. However, these effects were blocked by metformin. These findings suggest that blockade of IL-6-induced epithelial-mesenchymal transition is an antitumor mechanism of metformin.
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2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
3. Graduate School > Graduate School > 1. Journal Articles
4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

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Kang, Sang hee
구로병원 (Department of Colon and Rectal Surgery, Guro Hospital)
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