Detailed Information

Cited 9 time in webofscience Cited 9 time in scopus
Metadata Downloads

Changes in heart rate variability in first-episode drug-naive adolescents with major depressive disorder: A 12-week prospective study

Authors
Park, Sang-wonLee, Jong-haKim, JihyunSuh, SangilLee, Moon-Soo
Issue Date
1-Oct-2018
Publisher
ELSEVIER
Keywords
Major depressive disorder; Heart rate variability; Adolescent; Autonomic nervous system; Prospective studies
Citation
JOURNAL OF AFFECTIVE DISORDERS, v.238, pp 250 - 255
Pages
6
Indexed
SCI
SCIE
SSCI
SCOPUS
Journal Title
JOURNAL OF AFFECTIVE DISORDERS
Volume
238
Start Page
250
End Page
255
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3037
DOI
10.1016/j.jad.2018.05.068
ISSN
0165-0327
1573-2517
Abstract
Background: Major depressive disorder (MDD) is a common mental disorder, the onset of which frequently occurs during adolescence. While differences in heart rate variability (HRV) between depressed and healthy participants have previously been observed, results have been inconsistent. This study thus investigated the features of HRV in adolescents with MDD. Methods: We recruited first-episode drug-naive adolescents aged 13-18 years who had been diagnosed with MDD, and healthy age-matched controls. HRV was measured before and after a 12-week antidepressant treatment. We compared HRV measures between patient group and control group. We also tried to find correlation between HRV measures and depression rating scales. Results: Fifty-seven participants were included (patient group: n=31; control group: n=26). The patient group showed a lower normalized high frequency (HF norm), a higher normalized low frequency (LF norm), and a higher LF/HF ratio than did the control group. After treatment, LF was significantly decreased within the patient group compared to baseline. Hamilton Depression Rating Scales and Children's Depression Inventory scores were positively correlated with LF norm and LF/HF ratio, and negatively correlated with HF norm, when included all participants in analysis Limitations: Sample size of this study was small to assess influences of confounding factors on HRV. And follow up period was relatively short to see impact of pharmacotherapy. Conclusion: An imbalance of the autonomic nervous system might be a meaningful feature of adolescent MDD, and HRV might represent a potential biological marker for pathophysiological changes in MDD.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Radiology > 1. Journal Articles
2. Clinical Science > Department of Neurology > 1. Journal Articles
2. Clinical Science > Department of Psychiatry > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Suh, Sang Il photo

Suh, Sang Il
Guro Hospital (Department of Radiology, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE