Gender differences in clinical outcomes after percutaneous coronary interventions with zotarolimus-eluting stents: Insights from the Korean endeavor registry
- Authors
- Song P.S.; Song Y.B.; Hahn J.-Y.; Kim D.-I.; Yang J.H.; Choi S.-H.; Choi J.-H.; Gwon H.-C.; Park H.S.; Lee S.; Han K.-R.; Rha S.-W.; Cho B.R.; Park J.-S.; Yoon J.; Lim D.S.
- Issue Date
- Dec-2013
- Publisher
- Lippincott Williams and Wilkins
- Keywords
- Drug-eluting stent; Gender; Percutaneous transluminal coronary angioplasty
- Citation
- American Journal of the Medical Sciences, v.346, no.6, pp 479 - 485
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- American Journal of the Medical Sciences
- Volume
- 346
- Number
- 6
- Start Page
- 479
- End Page
- 485
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/30624
- DOI
- 10.1097/MAJ.0b013e318297bd98
- ISSN
- 0002-9629
1538-2990
- Abstract
- BACKGROUND:: The impact of gender on outcomes after percutaneous coronary intervention (PCI) with second-generation drug-eluting stents is not known in Asian patients. The authors studied outcomes after PCI with zotarolimus-eluting stent in unselected consecutive series of Asian patients according to gender. METHODS:: Outcomes among patients treated with zotarolimus-eluting stents from multicenter registry were evaluated by gender. The primary outcome was major adverse cardiac events, composite of cardiac death, myocardial infarction and target lesion revascularization at 1 year. RESULTS:: Of 2,840 patients, 855 (30.1%) were women. Comparatively, women were older; more frequently had diabetes, hypertension, and dyslipidemia; less frequently women were current smokers, had previous myocardial infarctions and previous PCIs; were more likely to have culprit lesions in left anterior descending coronary artery; and underwent more multilesion PCIs. After adjustment for baseline differences, women were still at lower risk of major adverse cardiac events (38 [4.4%] versus 137 [6.9%], adjusted hazard ratio [HR]: 0.52, 95% confidence interval [CI]: 0.30-0.89, P = 0.018), mainly driven by target lesion revascularization (24 [2.8%] versus 106 [5.3%], adjusted HR: 0.41, 95% CI: 0.24-0.70, P = 0.001) at 1 year, although rates of cardiac death, myocardial infarction and stent thrombosis were similar between genders. These results were consistent after propensity score-matched population analysis (for major adverse cardiac events, adjusted HR: 0.36, 95% CI: 0.18-0.69, P = 0.012; for target lesion revascularization, adjusted HR: 0.32, 95% CI: 0.15-0.69, P = 0.004) and were also constant among various high-risk subgroups. CONCLUSIONS:: Despite greater baseline clinical and angiographic risk, the use of the zotarolimus-eluting stent is associated with favorable outcomes among Asian women treated with PCI. © 2013 Lippincott Williams & Wilkins.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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