Comparison of drug-eluting stents in acute myocardial infarction patients with chronic kidney diseaseopen access
- Authors
- Hachinohe D.; Jeong M.H.; Saito S.; Kim M.C.; Cho K.H.; Ahmed K.; Hwang S.H.; Lee M.G.; Sim D.S.; Park K.-H.; Kim J.H.; Hong Y.J.; Ahn Y.; Kang J.C.; Kim J.H.; Chae S.C.; Kim Y.J.; Hur S.H.; Seong I.W.; Hong T.J.; Choi D.; Cho M.C.; Kim C.J.; Seung K.B.; Chung W.S.; Jang Y.S.; Rha S.W.; Bae J.H.; Park S.J.
- Issue Date
- Dec-2012
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Chronic; Myocardial infarction; Renal insufficiency; Stents
- Citation
- Korean Journal of Internal Medicine, v.27, no.4, pp 397 - 406
- Pages
- 10
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Internal Medicine
- Volume
- 27
- Number
- 4
- Start Page
- 397
- End Page
- 406
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/30848
- DOI
- 10.3904/kjim.2012.27.4.397
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims: To determine which drug-eluting stents are more effective in acute myocardial infarction (MI) patients with chronic kidney disease (CKD). Methods: This study included a total of 3,566 acute MI survivors with CKD from the Korea Acute Myocardial Infarction Registry who were treated with stenting and followed up for 12 months: 1,845 patients who received sirolimus-eluting stents (SES), 1,356 who received paclitaxel-eluting stents (PES), and 365 who received zotarolimus-eluting stents (ZES). CKD was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2 calculated by the modification of diet in renal disease method. Results: At the 12-month follow-up, patients receiving ZES demonstrated a higher incidence (14.8%) of major adverse cardiac events (MACEs) compared to those receiving SES (10.1%) and PES (12%, p = 0.019). The ZES patients also had a higher incidence (3.9%) of target lesion revascularization (TLR) compared to those receiving SES (1.5%) and PES (2.4%, p = 0.011). After adjusting for confounding factors, ZES was associated with a higher incidence of MACE and TLR than SES (adjusted hazard ratio [HR], 0.623; 95% confidence interval [CI], 0.442 to 0.879; p = 0.007; adjusted HR, 0.350; 95% CI, 0.165 to 0.743; p = 0.006, respectively), and with a higher rate of TLR than PES (adjusted HR, 0.471; 95% CI, 0.223 to 0.997; p = 0.049). Conclusions: Our findings suggest that ZES is less effective than SES and PES in terms of 12-month TLR, and has a higher incidence of MACE due to a higher TLR rate compared with SES, in acute MI patients with CKD. © 2012 The Korean Association of Internal Medicine.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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