Analgesic effect and inhibition of prostaglandin E 2 activity and pro-inflammatory cytokines production by ethyl alcohol extract from new herbal formula
- Authors
- Kwon S.Y.; Lee H.S.; Lee S.H.; Im G.I.; Kim S.N.; Kim H.S.; Hwang S.W.; Hwang S.Y.
- Issue Date
- 2006
- Keywords
- Analgesic; Anti-inflammation; MMPs; Osteoarthritis; PGE 2
- Citation
- Korean Journal of Pharmacognosy, v.37, no.3, pp 136 - 142
- Pages
- 7
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 37
- Number
- 3
- Start Page
- 136
- End Page
- 142
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/31978
- ISSN
- 0253-3073
- Abstract
- New herbal formula (NHF) is the ethanol extract mixture of Puerariae radix, Artemisia capillaries and Perilla frutescens. We have investigated the effects on anti-inflammation by NHF and attempted acetic acid induced writhing to verify the analgesic effect. Macrophages and chondrocytes were obtained from mouse and rabbit. Inflammation was induced by interleukin-1, tumor necrosis factor-α, interferon-γ, and lipopolysaccharide. NHF showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, PGE 2 production, NO production, and MMP-9 expression in rabbit articular chondrocyte. In the writhing test, NHF exhibited a dose-dependent inhibition of writhing. Futhermore, NHF increased the activity of SOD. NHF have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of osteoarthritis.
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- Appears in
Collections - 2. Clinical Science > Department of Orthopedic Surgery > 1. Journal Articles
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