Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Association of IL-10 genotypes with cardiovascular risk factors in patients with hemodialysis

Full metadata record
DC FieldValueLanguage
dc.contributor.author고강지-
dc.contributor.author김정엽-
dc.contributor.author김명규-
dc.contributor.author서순용-
dc.contributor.author최혜민-
dc.contributor.author현영율-
dc.contributor.author부창수-
dc.contributor.author이지은-
dc.contributor.author성수아-
dc.contributor.author조상경-
dc.contributor.author조원용-
dc.contributor.author김형규-
dc.date.available2020-11-10T14:50:24Z-
dc.date.issued2005-05-
dc.identifier.issn1738-9364-
dc.identifier.issn2289-0769-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/32049-
dc.description.abstractBACKGROUND: Chronic systemic inflammation in ESRD patients due to uremia and hemodialysis procedure itself comes into notice as a main factor for premature mortality secondary to rapid progressing atherosclerosis. Various pro-inflammatory cytokine, known to mediate these reaction of malnutrition, inflammation and atherosclerosis, are regulated by anti-inflammatory cytokine, such as IL-10. Quantitative production of IL-10 shows interindividual variability determined genetically by polymorphisms of promotor gene. The aim of this study was to measure the degree of IL-10 synthesis in ESRD patients treated with hemodialysis and evaluate the association with genotypes and cardiovascular risk factors. METHODS The IL-10 genotypes for polymorphic bases at position at -1082 was determined in 66 chronic hemodialysis patients and 98 healthy subjects using highly specific PCR and the lipopolysaccharide (LPS)-stimulated IL-10 (sIL-10) release from whole blood were measured by ELISA. RESULTS The distribution of the IL-10 genotypes in hemodialysis patients were similar to the general population, but the proportion of A allele in hemodialysis group was significantly higher (72.3% vs 59.8%, p=0.05). sIL-10 concentration were lower in hemodialysis patients compared with normal control (21.1 pg/mg vs 36.1 pg/mg, p=0.001) and both groups showed same relationship of sIL-10 with genotypes, that AA type was low producer. In multiple regression analysis, sIL-10 of normal group correlated negatively with age, creatinine, uric acid and existence LVH, and positively with albumin, hemoglobin. On the other hand, lower albumin, lower ejection fraction on echocardiography and existence of left ventricular hypertrophy were associated with higher sIL-10 in hemodialysis group. CONCLUSION Polymorphisms by IL-10 genotypes were associated with production of IL-10 by endotoxin stimulation, and sIL-10 was lower in hemodialysis patients than in normal control. According to relation of sIL-10 with cardiovascular risk factors such as existence LVH, ejection fraction and malnutrition, it could be suggested that sIL-10 is useful marker in evaluating the risk of cardiovascular events.-
dc.format.extent9-
dc.publisher대한내과학회-
dc.titleAssociation of IL-10 genotypes with cardiovascular risk factors in patients with hemodialysis-
dc.title.alternative혈액투석을 시행하는 만성 신부전 환자에서 IL-10 유전자형 및 혈중농도와 심혈관계 합병증과의 관계에 대한 고찰-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.bibliographicCitation대한내과학회지, v.68, no.5, pp 528 - 536-
dc.citation.title대한내과학회지-
dc.citation.volume68-
dc.citation.number5-
dc.citation.startPage528-
dc.citation.endPage536-
dc.identifier.kciidART000933622-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasskci-
dc.subject.keywordAuthorInterleukin-10-
dc.subject.keywordAuthorPolymorphism-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorCardiovascular disease-
dc.identifier.urlhttps://www.ekjm.org/journal/view.php?number=14686-
Files in This Item
Go to Link
Appears in
Collections
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Myung Gyu photo

Kim, Myung Gyu
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE