Detailed Information

Cited 5 time in webofscience Cited 6 time in scopus
Metadata Downloads

Sphincter of Oddi dysfunction: sphincter of Oddi dysfunction or discordance? What is the state of the art in 2018?

Authors
Hyun, Jong JinKozarek, Richard A.
Issue Date
Sep-2018
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
endoscopic sphincterotomy; idiopathic acute relapsing pancreatitis; sphincter of Oddi dysfunction; sphincter of Oddi manometry
Citation
CURRENT OPINION IN GASTROENTEROLOGY, v.34, no.5, pp.282 - 287
Indexed
SCIE
SCOPUS
Journal Title
CURRENT OPINION IN GASTROENTEROLOGY
Volume
34
Number
5
Start Page
282
End Page
287
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3205
DOI
10.1097/MOG.0000000000000455
ISSN
0267-1379
Abstract
Purpose of reviewTo review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD).Recent findingsThe long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing that neither endoscopic retrograde cholangiopancreatography-manometry nor endoscopic sphincterotomy are appropriate for SOD type III. Pain management in the latter patients has reverted to neuromodulating agents, and recent studies have suggested a role for duloxetine and potentially acupuncture. The functional role of the sphincter of Oddi has been reiterated with a report demonstrating a higher clinically significant pancreatic fistula rate in distal pancreatectomy patients treated with higher doses of postoperative narcotics. Moreover, the injection of periampullary botulinum toxin preoperatively has been shown to decrease these fistulas in a pilot trial. Additional studies have reinforced that eluxadoline can cause sphincter of Oddi spasm and pancreatitis. In contrast to approaching patients with acute relapsing pancreatitis using endoscopic retrograde cholangiopancreatography and manometry, previous and current studies suggest that endoscopic ultrasound should be done first and the role of SOD in idiopathic acute relapsing pancreatitis remains controversial. Finally, there remain widespread disparities in practice patterns in the approach to patients currently classified as SOD type II.SummaryIn contrast to historical manuscripts which stress the classical definitions of three types of SOD and their consequences, more recent manuscripts on this topic have focused on improving surgical outcomes based on the physiologic role of sphincter of Oddi, as well as the pharmacologic causes and treatments of SOD. The simplistic view that SOD, however it has been diagnosed, requires biliary or dual sphincterotomy is just that, simplistic and potentially misguided.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Hyun, Jong Jin photo

Hyun, Jong Jin
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE