Intracellular interleukin-32 gamma mediates antiviral activity of cytokines against hepatitis B virusopen access
- Authors
- Kim, Doo Hyun; Park, Eun-Sook; Lee, Ah Ram; Park, Soree; Park, Yong Kwang; Ahn, Sung Hyun; Kang, Hong Seok; Won, Ju Hee; Ha, Yea Na; Jae, ByeongJune; Kim, Dong-Sik; Chung, Woo-Chang; Song, Moon Jung; Kim, Kee-Hwan; Park, Seung Hwa; Kim, Soo-Hyun; Kim, Kyun-Hwan
- Issue Date
- Aug-2018
- Publisher
- Nature Publishing Group
- Citation
- Nature Communications, v.9, no.1
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Nature Communications
- Volume
- 9
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3254
- DOI
- 10.1038/s41467-018-05782-5
- ISSN
- 2041-1723
- Abstract
- Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-gamma in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription and replication. The gamma isoform of IL-32 (IL-32 gamma) inhibits viral enhancer activities by downregulating liver-enriched transcription factors. Our data are validated in both an in vivo HBV mouse model and primary human hepatocytes. This study thus suggests that IL-32 gamma functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance.
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- Appears in
Collections - 2. Clinical Science > Department of Hepato-Biliary-Pancreatic Surgery > 1. Journal Articles
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