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Cited 37 time in webofscience Cited 38 time in scopus
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Long-Term Clinical Outcomes of Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer: A Prospective Multicenter Cohort Studyopen access

Authors
Kim, Sang GyunPark, Chan MiLee, Na RaeKim, JiyoungLyu, Da HyunPark, Seung-HeeChoi, Il JuLee, Wan SikPark, Seun JaKim, Jae JunKi, Ji HyunLim, Chul-HyunCho, Joo YoungKim, Gwang HaLee, Yong ChanJung, Hwoon-YongLee, Jun HaengChun, Hoon JaiSeol, Sang-Yong
Issue Date
Jul-2018
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Survival; Endoscopic mucosal dissection; Stomach neoplasms
Citation
GUT AND LIVER, v.12, no.4, pp.402 - 410
Indexed
SCIE
SCOPUS
KCI
Journal Title
GUT AND LIVER
Volume
12
Number
4
Start Page
402
End Page
410
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3384
DOI
10.5009/gnl17414
ISSN
1976-2283
Abstract
Background/Aims: Endoscopic submucosa I dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during-follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies.
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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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