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Cited 7 time in webofscience Cited 7 time in scopus
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Validation of risk prediction scores for hepatocellular carcinoma in patients with chronic hepatitis B treated with entecavir or tenofovir

Authors
Chang, Jin WonLee, Jae SeungLee, Hye WonKim, Beom KyungPark, Jun YongKim, Do YoungAhn, Sang HoonSeo, Yeon SeokLee, Han AhKim, Mi NaLee, Yu RimHwang, Seong GyuRim, Kyu SungUm, Soon HoTak, Won YoungKweon, Young OhPark, Soo YoungKim, Seung Up
Issue Date
Jan-2021
Publisher
WILEY
Citation
JOURNAL OF VIRAL HEPATITIS, v.28, no.1, pp.95 - 104
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF VIRAL HEPATITIS
Volume
28
Number
1
Start Page
95
End Page
104
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/33978
DOI
10.1111/jvh.13411
ISSN
1352-0504
Abstract
Several prediction scores for the early detection of hepatocellular carcinoma (HCC) are available. We validated the predictive accuracy of age, albumin, sex, liver cirrhosis (AASL), RESCUE-B, PAGE-B and modified PAGE-B (mPAGE-B) scores in chronic hepatitis B (CHB) patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF). Between 2007 and 2014, 3171 patients were recruited (1645, ETV; 1517, TDF). The predictive accuracy of each prediction score was assessed. The mean age of the study population (1977 men; 1194 women) was 48.8 years. Liver cirrhosis was present in 1040 (32.8%) patients. During follow-up (median, 58.2 months), 280 (8.8%) patients developed HCC; these patients were significantly older; more likely to be male; had significantly higher proportions of liver cirrhosis, hypertension and diabetes; and had significantly higher values for the four risk scores than those who did not develop HCC (allP < .05). Older age (hazard ratio [HR] = 1.048), male sex (HR = 2.142), liver cirrhosis (HR = 3.144) and prolonged prothrombin time (HR = 2.589) were independently associated with an increased risk of HCC (allP < .05), whereas a higher platelet count (HR = 0.996) was independently associated with a decreased risk of HCC (P < .05). The predictive accuracy of AASL score was the highest for 3- and 5-year HCC predictions (areas under the curve [AUCs] = 0.818 and 0.816, respectively), followed by RESCUE-B, PAGE-B and mPAGE-B scores (AUC = 0.780-0.815 and 0.769-0.814, respectively). In conclusion, four HCC prediction scores were assessed in Korean CHB patients treated with ETV or TDF. The AASL score showed the highest predictive accuracy.
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2. Clinical Science > Department of Cardiology > 1. Journal Articles
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Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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