Comparison of oral steroid regimens for acute acoustic trauma caused by gunshot noise exposure
- Authors
- Choi N.; Kim J.S.; Chang Y.-S.
- Issue Date
- 2019
- Publisher
- Cambridge University Press
- Keywords
- Acoustic Trauma; Hearing Loss, Noise-Induced; Oral Drug Administration; Prednisolone; Steroids
- Citation
- Journal of Laryngology and Otology, v.133, no.7, pp 566 - 570
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Laryngology and Otology
- Volume
- 133
- Number
- 7
- Start Page
- 566
- End Page
- 570
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/34062
- DOI
- 10.1017/S002221511900121X
- ISSN
- 0022-2151
1748-5460
- Abstract
- Background There are no definite guidelines regarding the most adequate steroid regimens for acute acoustic trauma.Objective To elucidate the dose-dependent differing benefits of oral steroids on hearing improvement following acute acoustic trauma.Methods Twenty-nine patients treated with oral steroids following a diagnosis of unilateral acute acoustic trauma were retrospectively reviewed. Patients were sorted into two groups with an oral steroid regimen. Group 1 received a 14-day course of treatment: 60 mg prednisolone daily for 10 days, tapering off over days 11-14. Group 2 received prednisolone for a total of 10 days: 60 mg for 5 days, tapering down each day for the remainder. Multivariable linear regression analysis was performed to evaluate the factors associated with the hearing gain.Results In the multivariable regression (R2 = 0.51, p < 0.001), patients in group 1 showed more significant improvement in the degree of hearing gain compared to group 2 (p = 0.03).Conclusion After comparing the differing benefits of oral steroids on hearing improvement by dosage, we recommend a high dose of prednisolone (60 mg per day) for 10 days, tapering over the remaining 4 days, for better hearing recovery following acute acoustic trauma. ? 2019 JLO (1984) Limited.
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