Detailed Information

Cited 3 time in webofscience Cited 3 time in scopus
Metadata Downloads

Paroxetine versus Venlafaxine and Escitalopram in Korean Patients with Major Depressive Disorder: A Randomized, Rater-blinded, Six-week Studyopen access

Authors
Woo, Young SupMcIntyre, Roger S.Kim, Jung-BumLee, Min-SooKim, Jae-MinYim, Hyeon WooJun, Tae-Youn
Issue Date
Nov-2017
Publisher
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
Keywords
Paroxetine; Venlafaxine; Escitalopram; Major depressive disorder; Korean
Citation
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.15, no.4, pp.391 - 401
Indexed
SCIE
SCOPUS
KCI
Journal Title
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Volume
15
Number
4
Start Page
391
End Page
401
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/34148
DOI
10.9758/cpn.2017.15.4.391
ISSN
1738-1088
Abstract
Objective: The purpose of this study was to compare the efficacy and safety of escitalopram, paroxetine and venlafaxine in Korean patients with major depressive disorder (MDD). Methods: A total of 449 Korean MDD patients were recruited in a six-week, randomized, rater-blinded, active-controlled trial and were evenly randomized to paroxetine, venlafaxine, or escitalopram treatment. Results: When comparing the mean difference for the Montgomery-angstrom sberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating Scale (HDRS) total scores during six weeks, paroxetine (-6.4 +/- 0.4, and -5.4 +/- 0.4, respectively) was found to be significantly superior to escitalopram (-3.7 +/- 0.5 and -3.1 +/- 0.4, respectively). Venlafaxine had a significantly lower MADRS total score (-5.4 +/- 0.4) than escitalopram. When adjusting baseline variables, the response, according to the MADRS and HDRS scores, in the paroxetine group was greater than that for the escitalopram group (odds ratio [OR]=2.43, 95% confidence interval [CI]=1.42-4.16 for MADRS; and OR=2.32, 95% CI=1.35-3.97 for HDRS) and the venlafaxine group (OR=1.94, 95% CI=1.17-3.21 for MADRS; and OR=1.71, 95% CI=1.03-2.83 for HDRS). Despite that the overall tolerability was high and similar among the three groups, a total of 268 subjects (59.7%) prematurely discontinued treatment, representing the main limitation of the present study. Conclusion: Although a low study completion rate limits generalizability, our findings suggest that paroxetine might be superior to escitalopram in Korean MDD patients. Further studies should be conducted to draw a definite conclusion.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Psychiatry > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Min Soo photo

Lee, Min Soo
Anam Hospital (Department of Psychiatry, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE