Paroxetine versus Venlafaxine and Escitalopram in Korean Patients with Major Depressive Disorder: A Randomized, Rater-blinded, Six-week Studyopen access
- Authors
- Woo, Young Sup; McIntyre, Roger S.; Kim, Jung-Bum; Lee, Min-Soo; Kim, Jae-Min; Yim, Hyeon Woo; Jun, Tae-Youn
- Issue Date
- Nov-2017
- Publisher
- KOREAN COLL NEUROPSYCHOPHARMACOLOGY
- Keywords
- Paroxetine; Venlafaxine; Escitalopram; Major depressive disorder; Korean
- Citation
- CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.15, no.4, pp 391 - 401
- Pages
- 11
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
- Volume
- 15
- Number
- 4
- Start Page
- 391
- End Page
- 401
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/34148
- DOI
- 10.9758/cpn.2017.15.4.391
- ISSN
- 1738-1088
2093-4327
- Abstract
- Objective: The purpose of this study was to compare the efficacy and safety of escitalopram, paroxetine and venlafaxine in Korean patients with major depressive disorder (MDD). Methods: A total of 449 Korean MDD patients were recruited in a six-week, randomized, rater-blinded, active-controlled trial and were evenly randomized to paroxetine, venlafaxine, or escitalopram treatment. Results: When comparing the mean difference for the Montgomery-angstrom sberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating Scale (HDRS) total scores during six weeks, paroxetine (-6.4 +/- 0.4, and -5.4 +/- 0.4, respectively) was found to be significantly superior to escitalopram (-3.7 +/- 0.5 and -3.1 +/- 0.4, respectively). Venlafaxine had a significantly lower MADRS total score (-5.4 +/- 0.4) than escitalopram. When adjusting baseline variables, the response, according to the MADRS and HDRS scores, in the paroxetine group was greater than that for the escitalopram group (odds ratio [OR]=2.43, 95% confidence interval [CI]=1.42-4.16 for MADRS; and OR=2.32, 95% CI=1.35-3.97 for HDRS) and the venlafaxine group (OR=1.94, 95% CI=1.17-3.21 for MADRS; and OR=1.71, 95% CI=1.03-2.83 for HDRS). Despite that the overall tolerability was high and similar among the three groups, a total of 268 subjects (59.7%) prematurely discontinued treatment, representing the main limitation of the present study. Conclusion: Although a low study completion rate limits generalizability, our findings suggest that paroxetine might be superior to escitalopram in Korean MDD patients. Further studies should be conducted to draw a definite conclusion.
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