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Cited 10 time in webofscience Cited 12 time in scopus
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Gender differences in depressive symptom profiles and patterns of psychotropic drug usage in Asian patients with depression: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants study

Authors
Park, Seon-CheolLee, Min-SooShinfuku, NaotakaSartorius, NormanPark, Yong Chon
Issue Date
Sep-2015
Publisher
SAGE PUBLICATIONS LTD
Keywords
Depression; gender; depressive symptom profiles; second-generation antipsychotics; Asian
Citation
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, v.49, no.9, pp.833 - 841
Indexed
SCIE
SSCI
SCOPUS
Journal Title
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
Volume
49
Number
9
Start Page
833
End Page
841
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/34569
DOI
10.1177/0004867415579464
ISSN
0004-8674
Abstract
Objectives: The purpose of this study was to investigate whether there were gender-specific depressive symptom profiles or gender-specific patterns of psychotropic agent usage in Asian patients with depression. Method: Clinical data from the Research on Asian Psychotropic Prescription Patterns for Antidepressant study (1171 depressed patients) were used to determine gender differences by analysis of covariates for continuous variables and by logistic regression analysis for discrete variables. In addition, a binary logistic regression model was fitted to identify independent clinical correlates of the gender-specific pattern on psychotropic drug usage. Results: Men were more likely than women to have loss of interest (adjusted odds ratio=1.379, p=0.009), fatigue (adjusted odds ratio=1.298, p=0.033) and concurrent substance abuse (adjusted odds ratio=3.793, p=0.008), but gender differences in other symptom profiles and clinical features were not significant. Men were also more likely than women to be prescribed adjunctive therapy with a second-generation antipsychotic (adjusted odds ratio=1.320, p=0.044). However, men were less likely than women to have suicidal thoughts/acts (adjusted odds ratio=0.724, p=0.028). Binary logistic regression models revealed that lower age (odds ratio=0.986, p=0.027) and current hospitalization (odds ratio=3.348, p<0.0001) were independent clinical correlates of use of second-generation antipsychotics as adjunctive therapy for treating depressed Asian men. Conclusion: Unique gender-specific symptom profiles and gender-specific patterns of psychotropic drug usage can be identified in Asian patients with depression. Hence, ethnic and cultural influences on the gender preponderance of depression should be considered in the clinical psychiatry of Asian patients.
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