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Cited 29 time in webofscience Cited 31 time in scopus
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Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas

Authors
Min, Soo KeeKoh, Young HoPark, YunwoongKim, Hyo JungSeo, JinwonPark, Hye-RimCho, Seong JinKim, In Sun
Issue Date
Apr-2012
Publisher
KOREAN SOCIETY PATHOLOGISTS
Keywords
Acetylation; Deacetylation; Histone deacetylase inhibitors; Lymphoma
Citation
KOREAN JOURNAL OF PATHOLOGY, v.46, no.2, pp 142 - 150
Pages
9
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF PATHOLOGY
Volume
46
Number
2
Start Page
142
End Page
150
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/35083
DOI
10.4132/KoreanJPathol.2012.46.2.142
ISSN
1738-1843
2092-8920
Abstract
Background: It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma. Methods: We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis. Results: The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p<0.05). The degree of the expression of HAT1 was correlated with that of HDAC1 in cases of DLBCL or NKTCL (p<0.05). The degree of the expression of HAT1 and HDAC1 was correlated with a poor survival in cases of DLBCL or PTCL-NOS (p>0.05). Conclusions: HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.
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