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Cited 11 time in webofscience Cited 11 time in scopus
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The Relationship between Mast Cell Density and Tumour Grade in Transitional Cell Carcinoma of the Bladder

Authors
Kim, J. H.Kang, Y. J.Kim, D. S.Lee, C. H.Jeon, Y. S.Lee, N. K.Oh, M. H.
Issue Date
Sep-2011
Publisher
FIELD HOUSE PUBLISHING LLP
Keywords
BLADDER NEOPLASM; TRANSITIONAL CELL CARCINOMA; MAST CELL; TUMOUR GRADE; TOLUIDINE BLUE STAINING; IMMUNOHISTOCHEMISTRY; TRYPTASE
Citation
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.39, no.5, pp 1675 - 1681
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume
39
Number
5
Start Page
1675
End Page
1681
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/35180
DOI
10.1177/147323001103900509
ISSN
0300-0605
1473-2300
Abstract
This study investigated the relationship between mast cell numbers and the grade of bladder transitional cell carcinoma (TCC). Bladder TCC biopsies were obtained via transurethral resection and 45 stage T1 specimens were included in the study. Specimens were sorted into two groups, low grade (grade I) and high grade (grades II and III). Samples were stained using haematoxylin and eosin, toluidine blue and immunohistochemical staining for tryptase. Mast cells were examined by light microscopy and cell density was recorded. Mast cell density was significantly higher in high-grade TCC than low-grade TCC. There was also a significant relationship between the number of mast cells identified using toluidine blue staining or immunohistochemical staining for tryptase. Detailed studies of mast cell function will enable the development of more effective antitumour therapies via mast cell manipulation.
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