Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: the CRESCEND study
- Kim, Jae-Min; Kim, Sung-Wan; Stewart, Robert; Kim, Seon-Young; Yoon, Jin-Sang; Jung, Sung-Won; Lee, Min-Soo; Yim, Hyeon-Woo; Jun, Tae-Youn
- Issue Date
- John Wiley & Sons Inc.
- depression; remission; anxiety; parasuicide; Korea
- Human Psychopharmacology, v.26, no.1, pp.41 - 50
- Journal Title
- Human Psychopharmacology
- Start Page
- End Page
To estimate the 12-week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical setting in South Korea.
For people with DSM-IV depressive disorders about to receive treatment at 18 hospitals, data on sociodemographic and health status were obtained. A free choice of clinical interventions was allowed and naturalistic follow-up took place at 1, 2, 4, 8, and 12 weeks later. Remission was defined as a Hamilton Depression Rating Scale score of ≤7 sustained to 12 weeks or last follow-up, if earlier.
For 723 participants, the 12-week remission rate was 31.4%. Remission was more likely in women, and in patients without a prior history of suicide attempt, and those with lower baseline anxiety.
Remission associated with unrestricted clinical interventions was comparable to STAR*D estimates for citalopram alone. Comorbid anxiety and a previous suicide attempt were markers of worse outcome.
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- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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