Detailed Information

Cited 85 time in webofscience Cited 104 time in scopus
Metadata Downloads

A Shift in the Clinical Spectrum of Eosinophilic Gastroenteritis Toward the Mucosal Disease Type

Authors
Chang, Joseph Y.Choung, Rok SeonLee, Ru MinLocke, G. RichardSchleck, Cathy DZinsmeister, Alan R.Smyrk, Thomas C.Talley, Nicholas J.
Issue Date
Aug-2010
Publisher
ELSEVIER SCIENCE INC
Keywords
Eosinophilia; Gastroenteritis; Allergic Gastroenteropathy; Clinical Trial
Citation
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, v.8, no.8, pp 669 - 675
Pages
7
Indexed
SCIE
SCOPUS
Journal Title
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Volume
8
Number
8
Start Page
669
End Page
675
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/35379
DOI
10.1016/j.cgh.2010.04.022
ISSN
1542-3565
1542-7714
Abstract
Background & Aims Eosinophilic gastroenteritis (EG) is a rare disorder characterized by eosinophilic infiltration of the gastrointestinal (GI) tract. Despite the increasing prevalence of eosinophilic GI disorders, the epidemiology of EG has not been well studied. We evaluated the clinical spectrum of EG. Methods We reviewed data from patients diagnosed with EG, allergic gastroenteropathy, or eosinophilia and referred to gastroenterologists from 1987 to 2007 (n = 59; 52 with mucosal, 3 with muscularis, and 4 with subserosal disease). The study included subjects diagnosed with EG and those with a history that suggested EG, defined by GI symptoms; eosinophilic infiltration of the GI tract, eosinophilic ascites, or characteristic radiographic findings with eosinophilia; and no parasitic or extraintestinal disease. Findings were compared with those from patients with unexplained GI symptoms and peripheral eosinophilia (n = 11). Results Associations between clinical variables and EG subgroups did not differ between patients with EG and peripheral eosinophilia. Fifty percent of patients with EG who underwent food allergy testing had a positive test result; only 32% of those with EG who underwent radiographic imaging had positive test results. Patients with EG received steroid therapy; 75% with mucosal, 67% with muscle, and 100% with subserosal disease received prednisone. Eighty-eight percent of patients who received only steroids (mean follow-up period, 7 mo) and 94% of patients who received steroids in combination with another therapy (mean follow-up period, 4 mo) had improved or resolved disease. Conclusions Unlike eosinophilic esophagitis, EG is rare. Results from this large study suggest that EG disease type has shifted toward that of the mucosal layer.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE