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Cited 57 time in webofscience Cited 61 time in scopus
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Anti-integrin therapy for inflammatory bowel disease

Authors
Park, Sung ChulJeen, Yoon Tae
Issue Date
7-May-2018
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
Integrin; Ulcerative colitis; Crohn' s disease; Natalizumab; Abrilumab; Etrolizumab; PF-00547659; Inflammatory bowel disease; AJM300; Vedolizumab
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.24, no.17, pp.1868 - 1880
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
24
Number
17
Start Page
1868
End Page
1880
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3552
DOI
10.3748/wjg.v24.i17.1868
ISSN
1007-9327
Abstract
In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Anti-integrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and intestinal blood vessels. Natalizumab, which acts on alpha 4-integrin, was the first such drug to be approved for Crohn's disease, but its use is limited due to the risk of progressive multifocal leukoencephalopathy. Vedolizumab produces few systemic adverse effects because it acts on gut-trophic alpha 4 beta 7 integrin, and has been approved and is being used to treat IBD. Currently, several anti-integrin drugs, including etrolizumab, which acts on beta 7-integrin, and PF-00547569, which targets mucosal addressin cell adhesion molecule-1, are undergoing clinical trials and the results are being closely watched.
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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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