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Cited 213 time in webofscience Cited 211 time in scopus
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Clinical and genomic landscape of gastric cancer with a mesenchymal phenotypeopen access

Authors
Oh, Sang CheulSohn, Bo HwaCheong, Jae-HoKim, Sang-BaeLee, Jae EunPark, Ki CheongLee, Sang HoPark, Jong-LyulPark, Yun-YongLee, Hyun-SungJang, Hee-JinPark, Eun SungKim, Sang-CheolHeo, JeonghoonChu, In-SunJang, You-JinMok, Young-JaeJung, WonKyungKim, Baek-HuiKim, AereeCho, Jae YongLim, Jae YunHayashi, YukiSong, ShumeiElimova, ElenaEstralla, Jeannelyn S.Lee, Jeffrey H.Bhutani, Manoop S.Lu, YilingLiu, WenbinLee, JeeyunKang, Won KiKim, SungNoh, Sung HoonMills, Gordon B.Kim, Seon-YoungAjani, Jaffer A.Lee, Ju-Seog
Issue Date
May-2018
Publisher
Nature Publishing Group
Citation
Nature Communications, v.9
Indexed
SCI
SCIE
SCOPUS
Journal Title
Nature Communications
Volume
9
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3555
DOI
10.1038/s41467-018-04179-8
ISSN
2041-1723
Abstract
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival and resistance to standard chemotherapy, whereas the EP subtype is associated with better survival rates and sensitivity to chemotherapy. Integrative analysis shows that signaling pathways driving epithelial-to-mesenchymal transition and insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1R) pathway are highly activated in MP subtype tumors. Importantly, MP subtype cancer cells are more sensitive to inhibition of IGF1/IGF1R pathway than EP subtype. Detailed characterization of these two subtypes could identify novel therapeutic targets and useful biomarkers for prognosis and therapy response.
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2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Foregut Surgery > 1. Journal Articles
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles

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Kim, Ae ree
Guro Hospital (Department of Pathology, Guro Hospital)
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