A multicenter phase II trial of etoposide, methylprednisolone, high-dose cytarabine, and oxaliplatin for patients with primary refractory/relapsed aggressive non-Hodgkin's lymphoma
- Authors
- Sym, Sun Jin; Lee, Dae Ho; Kang, Hye Jin; Nam, Seung Hyun; Kim, Ho Young; Kim, Seok Jin; Eom, Hyeon Seok; Kim, Won Seog; Suh, Cheolwon
- Issue Date
- Jun-2009
- Publisher
- SPRINGER
- Keywords
- Oxaliplatin; Lymphoma; Salvage therapy; Chemotherapy
- Citation
- CANCER CHEMOTHERAPY AND PHARMACOLOGY, v.64, no.1, pp 27 - 33
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Volume
- 64
- Number
- 1
- Start Page
- 27
- End Page
- 33
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/35576
- DOI
- 10.1007/s00280-008-0847-y
- ISSN
- 0344-5704
1432-0843
- Abstract
- We investigated the efficacy and toxicity of the etoposide, methylprednisolone, high-dose cytarabine, and oxaliplatin (ESHAOx), in which oxaliplatin (Ox) was substituted for cisplatin in the ESHAP [etoposide (E), methylprednisolone (S), high-dose cytarabine (HA), and cisplatin (P)] regimen, for patients with refractory/relapsed aggressive non-Hodgkin's lymphoma (NHL). The ESHAOx consisted of E (40 mg/m(2) on days 1-4), S (500 mg on days 1-5), HA (2 g/m(2) on day 5), and Ox (130 mg/m(2) on day 1) every 3 weeks to a maximum of six cycles. Responses were assessed every three cycles. Twenty-seven patients were enrolled (19 with relapsed and 8 with refractory; 10 with an IPI score of 3-5). The overall response rate was 63% [95% confidence interval (95% CI) 45-81%], including eight complete remissions (CR) and one unconfirmed CR (33%). The median duration of response was 9.9 months (95% CI 5.7-14.2 months). After a median follow-up of 18.6 months, the median progression-free and overall survival was 5.3 months (95% CI 3.9-6.7 months) and 15.1 months (95% CI 9.4-20.9 months), respectively, with a 1-year survival rate of 61.5%. Most common grade 3/4 hematologic toxicities were neutropenia (56%) and thrombocytopenia (35%), whereas no patient experienced grade 3/4 renal or neurotoxicity. The efficacy and toxicity profiles suggested that the ESHAOx can be an alternative option for patients with refractory/relapsed aggressive NHL.
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Collections - 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
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