주요우울증환자에서 세로토닌 6(5-HT6) 수용체 C267T 다형성과 Citalopram 치료반응에 대한 연구

Abstract

The serotonin 6 (5-HT6) receptor gene is a candidate gene for influencing the clinical response to treatment with antidepressants. The purpose of this study was to determine the relationship between the C267T polymorphism in the 5-HT6 receptor gene and the treatment response to citalopram in a Korean population with major depressive disorder (MDD). Citalopram was administered for 8 weeks to the 90 patients who completed study. We found that the genotype, allele, and allele-carrier distributions did not differ significantly between MDD patients and normal controls. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8 weeks study period was not found. ANOVA revealed no significant effects of the C825T polymorphism on the decrease in the HAMD-21 score at each time period.These results suggest that the C267T polymorphism in the 5-HT6 receptor gene is not associated with citalopram treatment response. Key WordsMajor depressive disorder, 5-HT6 receptor , C267T polymorphism, citalopram.