Association study of the serotonin transporter promoter polymorphism and mirtazapine antidepressant response in major depressive disorder
- Authors
- Kang, Rhee-Hun; Wong, Ma-Li; Choi, Myoung-Jin; Paik, Jong-Woo; Lee, Min-Soo
- Issue Date
- 15-Aug-2007
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- 5-HTTLPR; MDD; mirtazapine
- Citation
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.31, no.6, pp 1317 - 1321
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Volume
- 31
- Number
- 6
- Start Page
- 1317
- End Page
- 1321
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/35861
- DOI
- 10.1016/j.pnpbp.2007.05.018
- ISSN
- 0278-5846
1878-4216
- Abstract
- Modulations of serotonergic and noradrenergic systems are thought to be critical to the therapeutic effect of most antidepressants, and their efficacies have been shown to depend on a functional polymorphism within the promoter region of the serotonin transporter gene (5-HTTLPR). Mirtazapine has a dual-action profile, combining the enhancement of the noradrenergic neurotransmitter system with specific actions on particular serotonergic receptor subtypes. The goal of this study was to elucidate whether the 5-HTTLPR polymorphism is associated with the mirtazapine antidepressant response in subjects with major depressive disorder (MDD). One hundred and one MDD patients were evaluated during 4 weeks of mirtazapine treatment. The severity of depression was assessed with the 21-item Hamilton Depression Rating scale, and the 5-HTTLPR genotypes in the patients were determined using the polymerase chain reaction. Our results showed that responses at the 2nd and 4th weeks were significantly better for the s/s genotype of the 5-HTTLPR polymorphism than for I-allele carriers. These results support our hypothesis that the response to noradrenergic and specific serotonergic antidepressants is significantly associated with the 5-HTTLPR polymorphism. (C) 2007 Elsevier Inc. All rights reserved.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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