Factors Associated with Rebleeding in Patients with Peptic Ulcer Bleeding: Analysis of the Korean Peptic Ulcer Bleeding (K-PUB) Study
- Kim, Joon Sung; Kim, Byung-Wook; Park, Sung Min; Shim, Ki-Nam; Jeon, Seong Woo; Kim, Sang-Wook; Lee, Yong Chan; Moon, Hee Seok; Lee, Si Hyung; Jung, Woon Tae; Kim, Jin Il; Kim, Kyoung Oh; Park, Jong-Jae; Chung, Woo Chul; Kim, Jeong Hwan; Baik, Gwang Ho; Oh, Jung Hwan; Kim, Sun Moon; Kim, Hyun Soo; Yang, Chang Heon; Jung, Jin Tae; Lim, Chul Hyun; Song, Hyun Joo; Kim, Yong Sik; Kim, Gwang Ha; Kim, Jie-Hyun; Chung, Jae-Il; Lee, Jun Haeng; Choi, Min Ho; Choi, Jong-Kyoung
- Issue Date
- 거트앤리버 발행위원회
- Peptic ulcer hemorrhage; Rebleeding; Risk factors
- Gut and Liver, v.12, no.3, pp.271 - 277
- Journal Title
- Gut and Liver
- Start Page
- End Page
Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB.
The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding.
In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations.
The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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