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Low GDP Solution(Multi-compartment bag)으로 복막투석을 시행한 환자에서 CA125 및 PIIINP(Procollagen-3-N-terminal Peptide)의 변화.Changes of CA125 and PIIINP (Procollagen-3-N-terminal Peptide) in Peritoneal Dialysis Patients with Low GDP Solution

Other Titles
Changes of CA125 and PIIINP (Procollagen-3-N-terminal Peptide) in Peritoneal Dialysis Patients with Low GDP Solution
Authors
김정엽부창수김명규고강지이지은신진호권영주표희정
Issue Date
Jan-2005
Publisher
대한신장학회
Keywords
GDP; CAPD; CA125; PIIINP
Citation
Kidney Research and Clinical Practice, v.24, no.1, pp 118 - 125
Pages
8
Indexed
KCI
Journal Title
Kidney Research and Clinical Practice
Volume
24
Number
1
Start Page
118
End Page
125
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/36375
ISSN
2211-9132
2211-9140
Abstract
Background:The bioincompatability of the conventional peritoneal dialysis can be partly attributed to the presence of GDPs, which are generated during the heat sterilization. Formation of GDPs can be significantly reduced by the use of multi-chamber bag systems because high concentrated glucose is separated from alkaline lactate. In order to investigate whether multi-chamber bag system can improve the in vivo biocompatibility, we performed a randomized, prospective study comparing the multi-chamber bag system with the conventional PD system, measuring CA125 and PIIINP levels in the effluent dialysates as well as the other clinical and biochemical parameters. Methods:Forty five patients who were stable on CAPD were enrolled randomly assigned to experiment group (n=27), and control group (n=18). Overnight effluent was collected for measurement of CA125 and PIIINP and the other clinical, biochemical parameters were compared including the number of peritonitis, the ultrafiltration volume. Results:In patients treated with the multiple chamber bag system, there were significantly higher levels of CA125 and PIIINP from 1 month. No clinical and biochemical parameters influenced on their levels. The incidence of peritonitis or ultrafiltration volume did not differ between the two groups. Conclusion:Using the low GDP solution resulted in a better preservation of peritoneal mesothelial mass and an improvement of local peritoneal homeostasis, which are supposed to contribute to the biocompatibility of peritoneal dialysis fluid. (Korean J Nephrol 2005;24(1):118-125)
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Guro Hospital (Department of Nephrology and Hypertension, Guro Hospital)
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