Follicular expression of c-Kit/SCF and inhibin-alpha in mouse ovary during development
- Authors
- Kang, JS; Lee, CJ; Lee, JM; Rha, JY; Song, KW; Park, MH
- Issue Date
- Nov-2003
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- mouse ovary; follicle; c-Kit/SCF; inhibin-alpha
- Citation
- JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, v.51, no.11, pp 1447 - 1458
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Volume
- 51
- Number
- 11
- Start Page
- 1447
- End Page
- 1458
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/36674
- DOI
- 10.1177/002215540305101105
- ISSN
- 0022-1554
1551-5044
- Abstract
- The mechanism of development of the ovarian follicles has been largely unknown. We performed an immunohistochemical (IHC) study to determine the follicular expressions of c-kit, SCF, and inhibin-alpha at different developmental stages in mouse ovary. Ovaries were obtained from 14 and 16 days post coitum and 2, 7, and 21 days post partum (dpp) mice. IHC for c-kit, SCF, and inhibin-a was carried out. c-Kit and SCF were expressed on oogonia regardless of the developmental stage. Immunoreactive c-kit and SCF antigens were expressed on oocytes of primordial and primary follicles of neonate mouse ovaries. In 21 dpp mouse ovary, the expression of c-kit/SCF in oocytes gradually decreased as the follicles developed. c-Kit/SCF was expressed strongly in oocytes of preantral follicles and weakly in granulosa and thecal cells. Inhibin-alpha was mainly expressed on granulosa cells of preantral and early antral follicles of the 21 dpp mouse ovaries. These findings suggest that the IHC expression of c-kit/SCF proteins is specific in all developmental stages of ovarian follicles and is decreased after the follicle starts to grow. The expression of inhibin-alpha is negatively correlated with the expression of c-kit/SCF in the ovarian follicles in mice.
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Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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