Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose
- Authors
- Shim, YJ; Do, HK; Ah, SY; Kim, YS; Seong, JK; Park, IS; Min, BH
- Issue Date
- Apr-2003
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- gall of Rhus chinensis; alpha-glucosidase inhibitor; postprandial hypoglycemic effect
- Citation
- JOURNAL OF ETHNOPHARMACOLOGY, v.85, no.2-3, pp 283 - 287
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ETHNOPHARMACOLOGY
- Volume
- 85
- Number
- 2-3
- Start Page
- 283
- End Page
- 287
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/36796
- DOI
- 10.1016/S0378-8741(02)00370-7
- ISSN
- 0378-8741
1872-7573
- Abstract
- The present study examined the inhibitory effect of aqueous extract from the gall of Rhus chinensis (AEGRC) on alpha-glucosidase activity, an enzyme responsible for digestion of carbohydrate to monosaccharides in the process of intestinal absorption. AEGRC inhibited Bacillus alpha-glucosidase acitvity with an IC50 of 0.9 mug/ml. Its inhibition on alpha-glucosidase was determined to be noncompetitive and reversible when the enzyme-substrate mixture was simultaneously treated with AEGRC as an inhibitor. In addition, when it was orally administered to rats with sucrose (2 g/kg), AEGRC (250-1000 mg/kg) significantly suppressed the increase of blood glucose levels after sucrose loading in a dose dependent manner. These results suggest that AEGRC might exert anti-diabetic effect by suppressing carbohydrate absorption from intestine, and thereby reducing the postprandial increase of blood glucose. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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Collections - 1. Basic Science > Department of Pharmacology > 1. Journal Articles
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