T-lymphocyte subsets in patients with AJCC stage III gastric cancer during postoperative adjuvant chemotherapy
- Authors
- Cho M.Y.; Joh Y.G.; Kim N.R.; Jung S.I.; Bae J.W.; Kim Y.C.; Koo B.H.; Whang C.W.; Suh S.O.
- Issue Date
- 2002
- Publisher
- Finnish Surgical Society
- Keywords
- Immunosuppression; Lymphocyte subsets; Recurrence; Stomach neoplasms
- Citation
- Scandinavian Journal of Surgery, v.91, no.2, pp 172 - 177
- Pages
- 6
- Indexed
- SCOPUS
- Journal Title
- Scandinavian Journal of Surgery
- Volume
- 91
- Number
- 2
- Start Page
- 172
- End Page
- 177
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/37135
- DOI
- 10.1177/145749690209100207
- ISSN
- 1457-4969
1799-7267
- Abstract
- Background and Aims: Advanced neoplastic diseases alter the immune response in cancer patients. The aim of this study was to evaluate the changes of T-lymphocyte subsets during postoperative adjuvant chemotherapy, and the relationship between T-lymphocyte subsets and tumor recurrence in AJCC stage III gastric cancers. Material and Methods: Analysis of T-lymphocyte subsets was performed in 39 patients with stage III gastric adenocarcinoma who had undergone a curative gastric resection and postoperative chemotherapy. Circulating T-lymphocyte subsets were measured on venous blood by using flow cytometry and monoclonal antibodies on preoperative day 1, and postoperative months 1, 3, and 6. Results: The 5-year disease-free survival rates of patients with stage 3a and 3b gastric cancer were 57.1 % and 33.3 %, respectively (p = 0.06). Values of CD3+ and CD4+ T-cells, and CD4+/CD8+ ratios were consistently lower in the recurrence group throughout the observation period. CD4+ T-cell counts were significantly lower in the recurrence group on preoperative day 1, and postoperative months 1 and 6. However, most values of the T-lymphocyte subsets showed no statistically significant difference when comparing the stage 3a and 3b disease patient groups. Conclusions: The results of this study suggest that immunosuppression associated with CD3+ and CD4+ T-cell depression is a risk factor for postoperative recurrence in patients with stage III gastric cancer.
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Collections - 2. Clinical Science > Department of Transplantation and Vascular Surgery > 1. Journal Articles
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- 2. Clinical Science > Department of Surgery > 1. Journal Articles
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