Aggressive intravenous hydration with lactated Ringer's solution for prevention of post-ERCP pancreatitis: a prospective randomized multicenter clinical trial
DC Field | Value | Language |
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dc.contributor.author | Park, Chang-Hwan | - |
dc.contributor.author | Paik, Woo Hyun | - |
dc.contributor.author | Park, Eun Taek | - |
dc.contributor.author | Shim, Chan Sup | - |
dc.contributor.author | Lee, Tae Yoon | - |
dc.contributor.author | Kang, Changdon | - |
dc.contributor.author | Noh, Myung Hwan | - |
dc.contributor.author | Yi, Sun Youn | - |
dc.contributor.author | Lee, Jong Kyun | - |
dc.contributor.author | Hyun, Jong Jin | - |
dc.contributor.author | Lee, Jun Kyu | - |
dc.date.available | 2020-11-02T07:41:44Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 0013-726X | - |
dc.identifier.issn | 1438-8812 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3716 | - |
dc.description.abstract | Background and study aims The present study aimed to determine the type of intravenous hydration that is best suited to reducing the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Patients and methods In a prospective randomized multicenter trial, average-to-high risk patients who underwent first-time ERCP were randomly assigned to three groups (1:1:1) who received: aggressive intravenous hydration (3 mL/kg/h during ERCP, a 20-mL/kg bolus and 3 mL/kg/h for 8 hours after ERCP) with either lactated Ringer’s solution (LRS) or normal saline solution (NSS), or standard intravenous hydration with LRS (1.5 mL/kg/h during and for 8 hours after ERCP). The primary end point was post-ERCP pancreatitis (PEP). Results 395 patients were enrolled, and 385 completed the protocols. The three groups showed no significant differences in demographic characteristics. There was a significant difference in the intention-to-treat (ITT) PEP rate between the aggressive LRS group (3.0 %, 95 % confidence interval [CI] 0.1 % – 5.9 %; 4 /132), the aggressive NSS group (6.7 %, 95 %CI 2.5 % – 10.9 %; 9 /134) and the standard LRS group (11.6 %, 95 %CI 6.1 % – 17.2 %; 15 /129; P = 0.03). In the two-group comparisons, the ITT PEP rate was significantly lower for the aggressive LRS group than for the standard LRS group (relative risk [RR] 0.26, 95 %CI 0.08 – 0.76; P = 0.008). There was no significant difference in the ITT PEP rate between the aggressive NSS group and the standard LRS group (RR 0.57, 95 %CI 0.26 – 1.27; P = 0.17). Conclusion Aggressive hydration with LRS is the best approach to intravenous hydration for the prevention of PEP in average-to-high risk patients. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Georg Thieme Verlag | - |
dc.title | Aggressive intravenous hydration with lactated Ringer's solution for prevention of post-ERCP pancreatitis: a prospective randomized multicenter clinical trial | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1055/s-0043-122386 | - |
dc.identifier.scopusid | 2-s2.0-85038351437 | - |
dc.identifier.wosid | 000431270800014 | - |
dc.identifier.bibliographicCitation | Endoscopy, v.50, no.4, pp 378 - 385 | - |
dc.citation.title | Endoscopy | - |
dc.citation.volume | 50 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 385 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | RECTAL INDOMETHACIN | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
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