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Cited 18 time in webofscience Cited 20 time in scopus
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HLA class II allele associations in Korean patients with pemphigus

Authors
Lee, CWYang, HYKim, SCJung, JHHwang, JJ
Issue Date
1998
Publisher
KARGER
Keywords
pemphigus vulgaris; pemphigus foliaceus; HLA class II allele
Citation
DERMATOLOGY, v.197, no.4, pp.349 - 352
Indexed
SCIE
SCOPUS
Journal Title
DERMATOLOGY
Volume
197
Number
4
Start Page
349
End Page
352
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/38225
DOI
10.1159/000018030
ISSN
1018-8665
Abstract
Background: Studies at the population level have demonstrated associations between pemphigus (pemphigus vulgaris, PV, and pemphigus foliaceus, PF) and particular HLA haplotypes, which suggests that there may be a genetic predisposition for the disease. Objective/Methods: The aim of the present study was to examine the distribution/frequency pattern of HLA class II alleles (DRB1, DQA1 and DQB1) from a group of 30 Korean patients with pemphigus (15 PV and 15 PF) by PCR amplification with sequence-specific primers. Results: In PV, the frequency of DRB1*01 allele was found to be significantly high (p(c)=0.0014); in PF, DRB1*01, DQA1*0302 and DQB1*0603 alleles showed positive associations with statistical significances (p(c)=0.0002, 0.0007 and 0.0067, respectively), when compared with those found in Korean controls. Conclusions: In this small-sample study, findings of allelic frequencies among Korean patients with pemphigus are somewhat different from those found in other populations.
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